The largest one was over 18 feet long and weighed more than 100 pounds, according to the Florida Fish and Wildlife Conservation Commission.
The female python was caught because of a new approach to finding pythons that include using male pythons with radio transmitters to locate breeding females.
She was captured after officials said pythons had to be rounded-up to stop their numbers getting out of control.
This enormous female was also found to contain 73 developing eggs.
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Pythons are invasive to Big Cypress, so the preserve's resource management staff works with the U.S. Geological Survey to "locate and remove" breeding pythons from the area.
"The team tracked one of the sentinel males with the transmitter and found this massive female nearby", the park said on Facebook.
A team of hunters with the Big Cypress National Preserve in Ochopee, Florida holding the female python which has 73 developing eggs.
Florida holds competitions in order to encourage hunters to remove these snakes and keep a check on their population. The snakes pose significant threats to native wildlife. Your information will be used in fighting this invasive species.
Last month, the battle against the invasive Burmese python in the Everglades reached a major milestone with the removal of the 2,000th python. While studies have shown populations of raccoons have dropped by 99.3 per cent, opossums by 98.9 per cent and bobcats by 87.5 per cent in the areas of the Everglades where pythons have been established longest.