After the big FSU second-half run, the closest the Cavs would get the rest of the way was 6 points with just 55 seconds left, but Terance Mann's breakaway dunk in the closing seconds put the icing on the cake.
Florida State and North Carolina both circled the wagons inside the three-point line, daring Duke to beat them with threes, but Williamson's hustle and feel around the basket made both opponents pay for every lapse in that defensive discipline.
Barry Brown added 12 points, Kamau Stokes had 11 and Makol Mawien finished with 10 for the tournament's top seed, which advanced to play No. 5 seed Iowa State in the semifinals Friday night. A day later, Williamson & Co. posted 50 in the paint against North Carolina, the most the Heels had surrendered in eight years.
Florida State opened as nine-point underdogs with the total opening at 146.
If UNC can stay hot and play the type of basketball they have been for over a month, they have a good shot.
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Florida State was on the board first with a three and built a 20-10 lead at the 10:19 mark in the first half.
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The performance was the 19th time this season that Williamson has scored 20+ points.
U.Va. (29-2) advanced to play in Friday's semifinals against No. 4 seed Florida State.
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Seeded No. 2 in the East Region and No. 7 in the overall field that year by the selection committee, the Blue Devils were upset by No. 7 seed SC, 88-81, in a second-round game at Greenville, S.C. Gonzaga enters the tournament as the only non-ACC No. 1 seed.
The Blue Devils went 3-3 in those six games to put itself in danger of failing below the No. 1 seed line on the NCAA tournament bracket. But Virginia shot 63 percent after the break and scored 49 points with long runs of efficient offense to go with tough defense.
Duke: This tournament has largely been about Williamson's return from the injury that had sidelined him for almost six full games, and what it means for the Blue Devils going forward.
In that game Zion Williamson did not play in the second half due to an eye injury, but the Seminoles were led by the 24 points, 10 rebounds, two steals, and three blocks from Kabengele, in addition to 21 points and seven rebounds from Cofer.
Even though the Seminoles are safely in the NCAA Tournament, a win over the Cavaliers could have massive seeding ramifications for Florida State. And that has fifth-ranked Duke celebrating yet another championship in its already-record haul.
And after Friday's prizefight, it might be that the final decision on which team is better will be made after yet another rematch in the NCAA tournament.
As usual, Williamson (+12) led the way with 21 points, five rebounds, two blocks and two assists. "We're going to get into the film room - tonight, probably - and get ready for the game tomorrow".
Keyshawn Woods scored 18, Kaleb Wesson added 17 points and a career-high 13 rebounds, and Ohio State hung on to beat IN in the second round.
"I'm trying to make the easy play", White said. He also had one rebound and two blocks.
"I told them last night: 'We've won a lot of championships but I haven't won one with you, '" Krzyzewski said during the trophy presentation.