After today's match, India and New Zealand would play the second T20I at Auckland on February 8 and the third T20I at Hamilton on February 10. India's previous worst was a 49-run loss to Australia back in 2010.
Seifert and Colin Munro blazed away at the top of the innings as New Zealand, looking to bounce back after being outplayed in the recent one-day global series, posted their third highest Twenty20 total of 219.
Chasing a record 220-run target, India stumbled to their biggest Twenty20 global defeat, the 80-run loss arriving in pursuit of a 220-run target at the Westpac Stadium in Wellington.
Only Mahendra Singh Dhoni offered resistance with a gritty 39 but the veteran wicketkeeper's effort went in vain as wickets tumbled at the other end.
In his post-match press conference, Seifert said he had watched quite a bit of McCullum growing up. "They batted really well and we bowled a few loose deliveries as well". New Zealand bowlers kept the pressure on Indian batsmen, especially the two spinners - left-arm orthodox Mitchell Santner and leg-spinner Ish Sodhi.
Meanwhile, the gesture shown by New Zealand's opening batsman Colin Munro during the first innings in Wellington was a shocking anti-thesis to all the unethical business in cricket.
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Earlier, Seifert made the most of two reprieves through dropped catches to smash seven fours and six boundaries en route to his maiden half-century.
There were shades of McCullum to some of Seifert's shots on Wednesday, particularly in the gallops down the track to the fast bowlers and the fast-hands slaps through cover point.
With Munro hitting Khaleel Ahmed for two successive sixes, New Zealand were off to a blazing start scoring 44 off the first four overs.
Even his approach to hitting in the shortest format appears to replicate that of the former Black Caps captain.
The elder Pandya finally got a breakthrough when Munro was caught in the deep off Vijay Shankar.