Manchester United have one of the worst defensive records in the league this season after conceding 32 goals in just 21 games this term.
And though his side could face as many as 65 fixtures if they went all the way in the cups, Guardiola said he would rather be fighting on multiple fronts as he believes momentum can apply across all competitions. They beat mythical teams - like Aston Villa and Middlesbrough.
"They got a massive squad of players that cost a fortune and earning a fortune, that's what you get in the Premier League so it's chalk and cheese".
Burton welcome City to their home ground for the second leg at the end of the month, and their manager Nigel Clough admitted he wanted his players to forget about the result.
"We do what we have to do to become a great, great club", said the Spaniard. We have to play second leg and we will take it seriously.
Manchester City's Gabriel Jesus celebrates scoring their fifth goal to complete his hat-trick at the Etihad Stadium in Manchester January 9, 2019. I saw a few minutes of games they played and they played good. Against Rotherham, for example, we played with nine players who didn't play against Liverpool and the nine were a good selection.
But while the scoreline threatened to put a dampener on the occasion - as did traffic problems on the road north from Burton - Clough said the club and their fans could still be proud.
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City, the Carabao Cup holders, are set to meet either Tottenham or Chelsea in the final, with Spurs leading 1-0 after Harry Kane's penalty gave them a first-leg victory at Wembley on Tuesday.
"But we still have an outside chance of achieving a miracle, and that's what we'll try for".
That was also why Guardiola was quick to run on to the pitch to speak to the Burton players at the full-time whistle. I wanted to congratulate them for an incredible tournament.
City, meanwhile, are in back on Monday night when they resume their Premier League venture against Wolverhampton Wanderers.
Liverpool legend Jamie Carragher responded to a dig from a City supporter by tweeting: "You can't fill your Stadium!"
"I take the cups seriously".
"In reality it's going to be hard but I'm sure all the players will go there in the right frame of mind".