Egypt's interior ministry has said at least 40 fighters have been killed on Saturday in response to an attack on a tourist bus in which four people killed the night before. The pyramids are in that region.
An interior ministry statement said 10 other tourists from Vietnam and the Egyptian bus driver were wounded when the homemade device exploded at 6:15 pm (1645 GMT).
The Prime Minister announced that the death toll, which was initially set at two Vietnamese tourists, had risen to three after the representative of the tour company on the trip succumbed to his injuries.
The bus was traveling in the Marioutiyah area near the pyramids when the crude roadside bomb, concealed by a wall, went off, Egypt's chief prosecutor Nabil Sadeq said in a statement.
Lan Le, 41, who was on the bus but unhurt, said they were going to see a sound and light show at the pyramids. "It was awful, people screaming", she told Reuters, speaking at al-Haram hospital, where the injured were taken.
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The bus's windscreen was covered in cracks and its side windows were blown out by the blast.
No militant group immediately claimed responsibility for the attack. "I don't remember anything after".
"The bus deviated from the route secured by the security forces", he told Extra News TV.
Egypt's foreign ministry spokesman Ahmed Hafez called Friday's attack a "cowardly" terrorist act targeting the willpower of the Egyptian people.
It said that 10 were seriously injured. "We will proceed together towards another year of persistence in uprooting terrorism", Hafez wrote on Twitter.