Syrian media have reported that air defenses were activated during an enemy strike on targets in the al-Kiswah region south of Damascus.
Israeli jets bombed several areas in southern Syria and near Damascus on Thursday drawing retaliatory fire from the ground, a monitoring group said.
Citing military sources, Syrian television said its air force had "successfully repelled enemy targets", but did not specifically identify the enemy or the targets.
According to the Syria Observatory for Human Rights, the strikes hit two positions in the south of Damascus province, one an area where there are Iranian weapons depots in Kisweh.
Damascus filed a complaint to the United Nations Security Council on Friday over the latest Israeli airstrikes against its territory.
The move raised fears in Israel that its ability to rein in Iran's military presence in Syria would be sharply reduced.
Hitting nothing was still enough for Israel to spend a solid hour striking targets around south Syria and metro Damascus.
An unconfirmed report from Ria Novosti said that an Israeli Air Force jet and four Israeli missiles were taken down.
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Another missile hit the area of Harfa, near the Israeli border, where there is a Syrian military base, the UK-based monitor said.
Note that the official confirmation of this information from the Israeli authorities did not arrive yet.
Regime media quoted a military source but did not specify what the target was or where it came from.
The Israeli military denied any of its assets were hit but stopped short of denying it had conducted strikes at all.
Iran is a key ally of Syrian President Bashar al-Assad and supports a number of militias that have fought alongside the Syrian army and its allies.
In recent years, Israel has acknowledged conducting hundreds of airstrikes in Syria, which it says were aimed at both preventing Iran from establishing a permanent military presence in Syria and blocking the transfer of advanced munitions to Hezbollah in Lebanon.
There was no evidence that the S-300 batteries were used to intercept Thursday night's missiles.