Argentine football star Lionel Messi suffered an injury in Barcelona's 4-2 win over Sevilla on Saturday, sending shockwaves across the Camp Nou, with fans anxious the club might struggle while the key playmaker recovers.
They host Barcelona in two weeks needing to win to ensure they have a better chance of topping the group.
Messi was 22 when Barcelona last played Inter, a 3-2 aggregate win for the Italians in the 2010 semi-finals that remains arguably the peak of Jose Mourinho's career.
It's going to happen again this weekend as Ronaldo has ventured to Serie A and Messi has picked up an arm injury.
Madrid have not lost in their last four visits to Barcelona, although those results came under coach Zinedine Zindane and with Cristiano Ronaldo leading the team that he left in the summer for Juventus.
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As the football world prepares for the latest installment of El Clasico, we want to see how well you really know this monumental feature.
For Valverde, Madrid are even more unsafe when they are desperate for a victory over their chief rival. And before Barcelona still have to play in the Champions League against inter. In history, Real Madrid has 72 wins in league over Barca, while Barca has 70, with 34 being draws.
Barcelona, which enters the match in second place at one point behind Atletico, will entrust Luis Suarez to lead the attack. Madrid created very little, and the likes of Ronaldo and Bale were kept quiet by the Catalonian defence.
MISSING GOALS When Real Madrid sold Ronaldo in July, fans and local media alike all asked the same question: how do you replace him?
However, Essien feels that Real Madrid can still win the El Clasico on Sunday, despite having won only one game in the last five and only scoring in the previous two.
"I'm looking at several options, several players who can play in that position or we could change the system".