With five minutes remaining against the Chiefs, the 49ers were trailing 38-24 when Garoppolo led them on a near-scoring drive in the final minutes, as Fox News previously reported. That's when the San Francisco quarterback headed for the sideline.
Kaepernick went 28-30 in five years as the 49ers' starter, throwing for 12,271 yards and 72 touchdowns.
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The team now has only two other quarterbacks on the roster. Beathard is now the only other quarterback on San Francisco's roster, so he'll presumably start in Garoppolo's absence barring a trade or free-agent signing.
The Niners struggled with Beathard and Brian Hoyer last season before the midseason addition of Garoppolo changed their fortunes. His loss is a crushing blow for the Niners, who just signed the 26-year-old to the richest contract in National Football League history this offseason and now must turn to backup quarterback C.J. Beathard to salvage their season.