The Portugal superstar headed home in just the fourth minute of the Group B encounter in Moscow to surpass former Hungary and Spain striker Ferenc Puskas and move his tally to 85 on his 152nd appearance for his country.
Then on Friday he doubled his record at the tournament and became only the fourth man to score in four different tournaments as he scored a match saving hat-trick to give Portugal a 3-3 draw with rivals Spain.
Morocco went on to lose the game 1-0, becoming the first team to be eliminated from the worldwide tournament.
"Please keep Pepe in your prayers after this assault from Benatia", the World Cup Goals account jokingly captioned the video.
Portugal will meet Iran in their final group game on June 25, with Morocco set to bow out after their match against Spain in Kaliningrad.
It was his 85th worldwide goal, taking him beyond Hungarian Ferenc Puskas's European record, with only Iran's Ali Daei ahead of him on 109.
Egyptian Football Association declares Mo Salah fit to face Russian Federation
If not - and it's most likely that Uruguay win - Egypt's match against Russian Federation will be enormous. The Barcelona striker is one of the best strikers in the world without doubt.
Despite their battling display, Morocco will rue the unforgivable defending that made all their subsequent good work irrelevant. The Atlas Lions wasted numerous chances to level and saw two first-half penalty claims rejected by referee Mark Geiger, with VAR not used, much to the dismay of coach Herve Renard.
Mehdi Benatia forced a smart low save from Rui Patricio at a corner for Morocco, before Hakim Ziyach skipped his way into the Portugal area, his goal-bound effort blocked by an outstretched leg. Ronaldo will look to close the gap further when Portugal face Iran on Monday.
Ronaldo's four goals top the individual scoring chart at the World Cup.
The veteran forward notched his third goal in two games when Ramin Rezaeian's attempted clearance bounced off the Spaniard's leg and into the net in the 54th minute.
For Portugal, a win today puts them in a good shape for qualification to the next round whilst Morocco must win today in order not to suffer the same fate as Egypt who virtually got kicked out yesterday.
"The Danish, they are a strong team", van Marwijk told reporters.